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KMID : 1225720180100060716
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Allergy, Asthma & Immunology Research : AAIR
2018 Volume.10 No. 6 p.716 ~ p.721
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Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children
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Yon Dong-Keon
An Jae-Woo
Ha Eun-Kyo
Jee Hye-Mi
Izuhara Kenji
Ono Junya
Jung Young-Ho
Lee Kyung-Suk
Sheen Youn-Ho
Baek Hey-Sung
Han Man-Yong
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Abstract
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Epidemiological studies have shown that exposure to tobacco smoke causing irritation and inflammation in the airways tends to reduce serum periostin concentrations in adults. We now investigate prospective cross-sectional study on 135 Korean students aged 7 years in the first grade who were participating in the Seongnam Atopy Project for Children's Happiness 2016 (SAP2016) cohort. To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children. Our findings suggested the need for caution in using the serum periostin level as a marker for allergic diseases, since exposure to volatile organic compounds and formaldehyde may confound the interpretation of these results.
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KEYWORD
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Periostin, volatile organic compounds, formaldehyde, children
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